A unique binding epitope for salvinorin A, a non‐nitrogenous kappa opioid receptor agonist
The FEBS Journal May 1, 2006 Brian E. Kane, Marcelo J. Nieto, Christopher R Mccurdy et al.
Salvinorin A is a potent kappa opioid receptor (KOP) agonist with unique structural and pharmacological properties. This non‐nitrogenous ligand lacks nearly all the structural features commonly associated with opioid ligand binding and selectivity. This study explores the structural basis to salvinorin A binding and selectivity using a combination of chimeric and single‐point mutant opioid...