Biased Signaling in Psychedelic Action.
Annu Rev Pharmacol Toxicol August 12, 2025 Daniel Wacker, John D. Mccorvy 4 citations
Psychedelics show tremendous promise for treating psychiatric disorders and other illnesses, including pain and migraine. Despite decades of research, there is uncertainty which signaling mechanisms are necessary for rapid-acting and durable therapeutic effects of psychedelics. Although activation of the serotonin 5-HT 2A receptor is critical for their psychopharmacological effects, the precise...