The small, globular cactus peyote (Lophophora williamsii) is known for its ability to produce mescaline, a phenethylamine protoalkaloid (Figure 1). Consuming the mescaline-containing dried tops or “buttons” of peyote has a psychedelic effect that has been used in religious ceremonies by Indigenous communities for over 5800 years (Cassels & Sáez-Briones, 2018). Nowadays, psychedelic drugs are...
Salvia divinorum commonly known as diviner's sage, is an ethnomedicinal plant of the mint family (Lamiaceae). Salvia divinorum is rich in clerodane-type diterpenoids, which accumulate predominantly in leaf glandular trichomes. The main bioactive metabolite, salvinorin A, is the first non-nitrogenous natural compound known to function as an opioid-receptor agonist, and is undergoing clinical...