The ABCs of psychedelics: a preclinical roadmap for drug discovery.
Trends Pharmacol Sci August 28, 2025 Alex C. Kwan, John R. Mantsch, John D. Mccorvy 7 citations
There is growing interest in developing psychedelic-inspired drugs for treating psychiatric disorders. However, identifying next-generation psychedelic analogs with ideal receptor selectivity and true therapeutic efficacy remains a major challenge. Recent progress has been driven by advances in determining agonist-induced biased signal transduction, high-content behavioral phenotyping via...