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The American Journal of Drug and Alcohol Abuse

ISSN 0095-2990, 1097-9891

33 papers in the library · 1,712 citations · publishing 1975-2025

Papers

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Diffusion Tensor Imaging in MDMA Users and Controls: Association with Decision Making

The American Journal of Drug and Alcohol Abuse 2007 F. Gerard Moeller, Joel L. Steinberg, Scott D Lane et al. 39 citations

Diffusion Tensor Imaging (DTI) may provide information regarding effects of 3,4-methylenedioxymethamphetamine (MDMA) use on brain structure. Twelve MDMA users and 20 healthy controls underwent whole brain DTI data acquisition. Fractional anisotropy (FA), mean diffusivity (D(av)), and longitudinal (lambda(1)) and transverse (lambda(T)) diffusivities were compared between MDMA users and controls...

DOI: 10.1080/00952990701651564 (opens in new tab) MDMA Ecstasy Corpus callosum Fractional anisotropy +6

An evaluation of phencyclidine (PCP) psychosis: a retrospective analysis at a state facility.

The American Journal of Drug and Alcohol Abuse 2006 Katie A Carls, Valerie L Ruehter

It has been reported in the literature that phencyclidine (PCP) psychosis recovery may take up to 4-6 weeks. This retrospective review sought to determine whether patients with a new onset of PCP psychosis have a longer hospitalization than those patients with new onset functional psychosis. The PCP arm (N = 20) was found to have a significantly shorter hospitalization than those with a new...

Toward a Comparative Overview of Dependence Potential and Acute Toxicity of Psychoactive Substances Used Nonmedically

The American Journal of Drug and Alcohol Abuse 1993 Robert S. Gable 105 citations

A procedure is outlined for comparing dependence potential and acute toxicity across a broad range of abused psychoactive substances. Tentative results, based on an extensive literature review of 20 substances, suggested that the margin of safety ("therapeutic index") varied dramatically between substances. Intravenous heroin appeared to have the greatest risk of dependence and acute lethality;...

DOI: 10.3109/00952999309001618 (opens in new tab) Psychoactive substance Acute toxicity Pharmacology Toxicology

Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function?

The American Journal of Drug and Alcohol Abuse 1992 John H. Krystal, Lawrence H. Price, Charles Opsahl et al. 171 citations

3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a selective serotonin (5-HT) neurotoxin in animals. There is now preliminary evidence in humans of 5-HT deficits associated with extensive use of MDMA. In order to begin to describe the cognitive and mood effects of chronic MDMA use, nine individuals with extensive MDMA use histories were studied. Despite the absence of memory deficits on...

Is phencyclidine (PCP) abuse associated with organic mental impairment?

The American Journal of Drug and Alcohol Abuse 1979 A S Carlin, I Grant, K M Adams et al.

The performance of sober (average length of abstinence = 27 months) phencyclidine (PCP) abusers on neuropsychological measures of organicity was compared to that of polydrug users who were not experienced with PCP, and to controls who were not alcohol or drug abusers. Six of 12 PCP users, five of 12 polydrug users, and none of the controls showed neuropsychological impairments. The deficits in...

Effects of cannabinoids on synaptic membrane enzymes. I. In vitro studies on synaptic membranes isolated from rat brain.

The American Journal of Drug and Alcohol Abuse 1976 C A Olmsted

The understanding of the effects of cannabinoids in human subjects has been obscured by a lack of knowledge about how the various active principles from marijuana act at the cellular level in the brain. For this reason the present study was undertaken to determine the effects of cannabinoids on the enzymes associated with the synaptic membranes. Electron micrographic analysis was performed to...

Social sanctions and rituals as a basis for drug abuse prevention.

The American Journal of Drug and Alcohol Abuse 1975 N E Zinberg, R C Jacobson, W M Harding

This paper will report on preliminary findings of an on-going study of "controlled" use of marihuana, psychedelics, and opiates which point to the possibility of minimizing the social costs of illicit drug use via social control. This study, sponsored by The Drug Abuse Council, Inc., a non-profit private foundation, shows that despite the lack of larger cultural support for controlled illicit...