Molecular Neurobiology

ISSN 0893-7648, 1559-1182

27 papers in the library · 120 citations · publishing 1995-2026

Papers

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The role of temperature, stress, and other factors in the neurotoxicity of the substituted amphetamines 3,4-methylenedioxymethamphetamine and fenfluramine.

Molecular Neurobiology August 1, 1995 D B Miller, J P O'Callaghan

Amphetamines (AMPs) can cause long-term depletions in striatal dopamine (DA) and serotonin (5-HT), and these decrements are often accepted as prima facie evidence of AMP-induced damage to the dopaminergic and serotonergic projections to striatum. Rarely are indices linked to neural damage used to evaluate the neurotoxicity of the AMPs. Here, we determined the potential neurotoxic effects of two...

DOI: 10.1007/bf02740694 Serotonin Corpus striatum Animals Mice, inbred c57bl +17

The use of toxicokinetics for the safety assessment of drugs acting in the brain.

Molecular Neurobiology 1995 D B Campbell

Pharmacological and toxicological studies undertaken on drugs that affect the brain are frequently performed in disparate species under various experimental conditions, at doses often greatly in excess of those expected to be administered to humans, and the findings are extrapolated implicitly or explicitly with scant regard to differences in the biodisposition of the drugs. Such considerations...

DOI: 10.1007/bf02740695 Full text