MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.
Alcohol (Fayetteville, N.Y.) 1995 S M Meehan, T L Gordon, M D Schechter
Selectively bred high- and low-alcohol-drinking (HAD/LAD) rats were trained to discriminate the interoceptive stimuli produced by IP-administered 600 mg/kg ethanol (10% w/v in a two-lever, food-motivated operant task. Once criterion discrimination was attained, animals were tested with 3.0, 1.5, 1.0, and 0.5 mg/kg MDMA. Although no differences in alcohol discrimination were observed between the...