Microdosing for early biokinetic studies in humans.
Radiation protection dosimetry 2010 K Stenström, M Sydoff, S Mattsson
Microdosing is a new concept in drug development that--if implemented in the pharmaceutical industry--would mean that new drugs can be tested earlier in humans than done today. The human microdosing concept--or 'Phase 0'--may offer improved candidate selection, reduced failure rates in the drug development line and a reduction in the use of laboratory animals in early drug development, factors...