Since the mid-1950s the pharmaceutical industry has developed a number of chemicals, including phencyclidine, ketamine and related arylcyclohexylamines (PCE and TCP), dizocilpine (MK-801), N-allylnormetazocine [ NANM, (±)SKF-10,047], etoxadrol, dioxadrol and its enantiomers dexoxadrol and levoxadrol, which produce a constellation of unusual behavioral effects in animals and man. The compounds...
In this article parallels are drawn between sleep and anaesthesia. Both can be described as 'behavioural states' in which stimulation and inhibition of certain neuronal groups will give rise to specific psychological states. The neuronal mechanisms leading to these states are reviewed and compared. Sensory information flow through the thalamus is reduced in sleep and anaesthesia, the thalamic...