N,N-dimethyltryptamine reduces infarct size and improves functional recovery following transient focal brain ischemia in rats
Experimental Neurology February 14, 2020 Sándor Nardai, Marcell J László, Attila Szabo et al. 91 citations
Background and purposeN,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain.MethodsTransient middle cerebral occlusion (MCAO) was induced for 60 min in male Wistar rats...