Intranasal Esketamine for Treatment-Resistant Depression with Structural Brain Abnormality: A Case Report
Psychiatry and Clinical Psychopharmacology November 13, 2025 Yu-Chih Shen, Chien-Chen Hung
This case report describes the clinical response and safety of intranasal esketamine (Spravato®) in a 61-year-old female with treatment-resistant depression (TRD), a history of electroconvulsive therapy (ECT) poor response, and structural brain abnormalities secondary to left frontal lobe tissue loss from traumatic brain injury in 2008. Despite multiple antidepressant trials, atypical...