New treatments for OCD? Evidence for cannabinoids and psychedelics.
J Psychiatr Res November 26, 2025 Michael van Ameringen, Vidhi Patel, Beth Patterson et al.
The etiology of OCD is complex and appears to involve multiple biological pathways. Imbalances in central serotonin, dopamine, and glutamate activities are widely thought to play a causative role. Despite strong evidence supporting first-line OCD pharmacotherapies, approximately 40-60 % of OCD patients remain unresponsive and are considered treatment resistant (TR). Although a range of agents...