Chris Timmermann

Pharmacokinetics of N,N-dimethyltryptamine in Humans.

European Journal of Drug Metabolism and Pharmacokinetics May 1, 2023 Meghan Good, Zelah Joel, Tiffanie Benway et al. 54 citations

N,N-dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). This study evaluated the preclinical and clinical pharmacokinetics and metabolism of DMT in healthy subjects. The physiochemical properties of DMT were determined using a series of in vitro experiments and its metabolic profile was assessed using monoamine oxidase (MAO)...