Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Nature Neuroscience June 1, 2023 Rafael Moliner, Mykhailo Girych, Vera Kovaleva et al. 439 citations
Abstract Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants. We recently reported that pharmacologically diverse antidepressants, including fluoxetine and ketamine, act by binding to TrkB, the receptor for BDNF. Here we show that lysergic acid diethylamide (LSD) and psilocin directly bind to...