A reciprocal interplay between 5-HT2A and mGlu5 receptors underlies neuroplasticity
bioRxiv Preprint Server July 23, 2025 Tomas Del Olmo, Mathilde Decourcelle, Martial Séveno et al. preprint
The serotonin (5-HT)2A receptor is the primary target of numerous psychoactive drugs including serotonergic psychedelics, and mediates psychedelics-induced neuroplasticity, but the signaling mechanisms involved remain poorly characterized. Using quantitative phosphoproteomics, we show that the administration of the hallucinogenic 5-HT2A receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) to...