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X. Zhao

1 paper in the library · 1 citation · publishing 2020

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Sleep deprivation rapidly upregulates serotonin 2A receptor expression via the immediate early gene Egr3

bioRxiv Preprint Server February 23, 2020 X. Zhao, K. T. Meyers, Andrew McBride et al. 1 citation preprint

Serotonin 2A receptors (5-HT2ARs) mediate the effects of hallucinogenic drugs and antipsychotic medications, and are reduced in schizophrenia patients’ brains. However, the mechanisms that regulate 5-HT2AR expression remain poorly understood. We show that an environmental stimulus, sleep deprivation, upregulates 5-HT2ARs in the mouse frontal cortex (FC) in just 6-8 hours. This induction...

DOI: 10.1101/634410 Full text