Structural Basis for Molecular Recognition of Cannabinoids by Inhibitory Cys-Loop Channels.
Journal of Medicinal Chemistry March 14, 2024 Lautaro D Alvarez, N R Carina Alves 7 citations
Cannabis sativa has a long history of medicinal use, dating back to ancient times. This plant produces cannabinoids, which are now known to interact with several human proteins, including Cys-loop receptors for glycine (GlyR) and gamma-aminobutyric acid (GABAAR). As these channels are the primary mediators of inhibitory signals, they contribute to the diverse effects of cannabinoids on the...