Biosynthesis of an Anti-Addiction Agent from the Iboga Plant.
Journal of the American Chemical Society August 21, 2019 Scott C. Farrow, Mohamed O. Kamileen, Lorenzo Caputi et al. 69 citations
(-)-Ibogaine and (-)-voacangine are plant derived psychoactives that show promise as treatments for opioid addiction. However, these compounds are produced by hard to source plants, making these chemicals difficult for broad-scale use. Here we report the complete biosynthesis of (-)-voacangine, and de-esterified voacangine, which is converted to (-)-ibogaine by heating, enabling biocatalytic...
DOI: 10.1021/jacs.9b05999 (opens in new tab)
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Substance abuse treatment
Anti-addiction agents
Opioid dependence solutions
Biocatalysis: biocatalytic synthesis
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