Ketamine’s acute effects on negative brain states are mediated through distinct altered states of consciousness in humans
Nature Communications October 19, 2023 Laura M Hack, Xue Zhang, Boris D. Heifets et al. 20 citations
Ketamine commonly and rapidly induces dissociative and other altered states of consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these experiences remain unknown. We used functional neuroimaging to engage key regions of the brain’s affective circuits during acute ketamine-induced ASCs within a randomized, multi-modal, placebo-controlled design examining placebo,...