The Effect of Ketamine on the Immune System in Patients with Treatment-Resistant Depression
International Journal of Molecular Sciences August 1, 2025 Łukasz P. Szałach, Klaudia Ciesielska-Figlon, A. Daca et al. 7 citations
Treatment-resistant depression (TRD) is associated with immune dysregulation. Ketamine, a rapid-acting antidepressant, may exert effects via immunomodulation. The aim was to examine ketamine’s impact on immune markers in TRD, including T-cell subsets, cytokines, and in vitro T-cell responses. Eighteen TRD inpatients received 0.5 mg/kg iv ketamine. Blood was sampled at baseline, 4 h, and 24 h to...