J. M. Crespo

Treatment-resistant depression and intranasal esketamine: Spanish consensus on theoretical aspects

Frontiers in Psychiatry August 4, 2025 Fernando Mora, J. Ramos-Quiroga, Enrique Baca-García et al. 5 citations

Introduction Depression is a highly prevalent disease that severely impacts the life of patients. Inadequate response to at least two antidepressants despite adequacy of treatment and adherence is known as treatment-resistant depression (TRD), which entails a higher social and economic burden than non-resistant major depression. The lack of consensus on the definition of TRD and other aspects...