Matthijs W Van Hoogdalem

Esketamine Nasal Spray: Mechanism of Action, Clinical, and Translational Science.

Clinical and Translational Science April 1, 2026 Matthijs W Van Hoogdalem, Dong-Jing Fu, Wayne C. Drevets et al.

Major depressive disorder (MDD) imposes a substantial burden worldwide, with treatment-resistant depression (TRD) and major depressive disorder with acute suicidal ideation or behavior (MDSI) representing two of the most severe clinical challenges. Conventional antidepressants often require several weeks to exert benefit, leaving patients symptomatic and at risk during this delay. Esketamine...