Prolonged ketamine infusion modulates limbic connectivity and induces sustained remission of treatment-resistant depression
Psychopharmacology January 22, 2021 J. Siegel, Ben J Palanca, Beau M Ances et al. 53 citations
Ketamine produces a rapid antidepressant response in over 50% of adults with treatment-resistant depression. A long infusion of ketamine may provide durable remission of depressive symptoms, but the safety, efficacy, and neurobiological correlates are unknown. In this open-label, proof-of-principle study, adults with treatment-resistant depression (N = 23) underwent a 96-h infusion of...