Inflammation, stress and depression: an exploration of ketamine’s therapeutic profile
Drug Discovery Today February 1, 2023 J. Johnston, Maximillian Greenwald, Ioline D. Henter et al. 64 citations
Well-established animal models of depression have described a proximal relationship between stress and central nervous system (CNS) inflammation – a relationship mirrored in the peripheral inflammatory biomarkers of individuals with depression. Evidence also suggests that stress-induced proinflammatory states can contribute to the neurobiology of treatment-resistant depression. Interestingly,...