Ketamine for rapid reduction of suicidal thoughts in major depression: a midazolam-controlled randomized clinical trial
American Journal of Psychiatry December 5, 2017 Michael F Grunebaum, Hanga C Galfalvy, Tse-Hwei Choo et al. 428 citations
Objective Pharmacotherapy to rapidly relieve suicidal ideation in depression may reduce suicide risk. Rapid reduction in suicidal thoughts after ketamine treatment has mostly been studied in patients with low levels of suicidal ideation. Method This randomized clinical trial tested the effect of adjunctive sub-anesthetic intravenous ketamine on clinically significant suicidal ideation in major...