Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
Neuron May 1, 2022 J. Lopez, M. Lücken, E. Brivio et al. 78 citations
A single sub-anesthetic dose of ketamine produces a rapid and sustained antidepressant response, yet the molecular mechanisms responsible for this remain unclear. Here, we identified cell-type-specific transcriptional signatures associated with a sustained ketamine response in mice. Most interestingly, we identified the Kcnq2 gene as an important downstream regulator of ketamine action in...