GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.
Journal of Clinical Investigation November 19, 2019 Danielle M. Gerhard, Santosh Pothula, Rong-Jian Liu et al. 345 citations
A single sub-anesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders. Ketamine produces a rapid increase in extracellular glutamate and synaptic formation in the prefrontal cortex, but the initial cellular trigger that initiates these and its...