Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability
Molecular Psychiatry April 15, 2021 Jordi Bonaventura, Sherry Lam, Meghan L. Carlton et al. 266 citations
Ketamine, a racemic mixture of (S)-ketamine and (R)-ketamine enantiomers, has been used as an anesthetic, analgesic and more recently, as an antidepressant. However, ketamine has known abuse liability (the tendency of a drug to be used in non-medical situations due to its psychoactive effects), which raises concerns for its therapeutic use. (S)-ketamine was recently approved by the United...