Indole therapeutics: Latest FDA updates, ongoing trials, and future directions.
Drug Discovery Today October 1, 2025 Noor-Ul-Huda Butt, Sultan Nacak Baytas 4 citations
Indole-based compounds serve as versatile pharmacophores across anticancer, antiviral, neurological, antimicrobial, and metabolic therapies. This review systematically analyses FDA-approved, withdrawn, and investigational indole-containing drugs over the past decade, focusing on evolving clinical outcomes, regulatory decisions, and therapeutic repositioning. It explores the shift from cytotoxic...