Jae-Gyeong Lee

2 papers in the library · 3 citations · publishing 2023-2024

Papers

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The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents

Archives of Pharmacal Research April 1, 2024 Young-Jung Kim, Wun-A Kook, Shi-Xun Ma et al. 3 citations

Novel psychoactive substances (NPSs) are new psychotropic drugs designed to evade substance regulatory policies. 25E-NBOMe (2-(4-ethyl-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine) has recently been identified as an NPS, and its recreational misuse has been reported to be rapidly increasing. However, the psychopharmacological effects and mechanisms of 25E-NBOMe have not been studied. We...

DOI: 10.1007/s12272-024-01491-4 Full text 25e-nbome Novel psychoactive substance Reward Dopamine d1 receptor +1

Designer Drug, 25D-NBOMe, Has Reinforcing and Rewarding Effects through Change of a Dopaminergic Neurochemical System.

ACS Chemical Neuroscience August 2, 2023 Jae-Gyeong Lee, Kwang-Hyun Hur, Su-Bin Hwang et al.

2-(2,5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)_ethanamine (25D-NBOMe), an analogue of the 2C family, is a newly synthesized psychoactive substance. It acts as an agonist at the 5-HT2A receptor and has a similar mechanism to that of NBOMe compounds. However, the pharmacological mechanism for its rewarding and reinforcing effects has not been revealed. In the present study, intravenous...

DOI: 10.1021/acschemneuro.3c00196 Full text Addiction 25d-nbome Cpp Dopamine +1