Persistent large-scale changes in alternative splicing in prefrontal cortical neuron types following psychedelic exposure.
bioRxiv : the preprint server for biology January 16, 2025 Yungyi Hsiao, Marcos As Fonseca, Alina S Tiemroth et al. preprint
Psychedelics engage the serotonergic system as potent neuromodulators, increasing neuroplasticity in humans and rodents. Persistent changes in cognitive flexibility, emotional regulation, and social cognition are thought to underlie the therapeutic effects of psychedelics. However, the underlying molecular and cellular basis of psychedelic-induced plasticity remains unclear. Here, we identify...