Psilocybin for Treatment of Prolonged Grief Disorder: An Open-Label Feasibility Study Protocol
Psychoactives April 13, 2026 J. Morgan Penberthy, Fatma Wise, Nicholas P. Cherup et al.
Prolonged grief disorder (PGD) affects approximately 10% of bereaved individuals and is now formally recognized in both the DSM-5-TR and ICD-11. Despite its prevalence, PGD often responds poorly to traditional therapeutic approaches. This manuscript outlines the protocol for an early-stage open-label feasibility trial investigating the use of psilocybin, a psychedelic compound, in treating PGD...
DOI: 10.3390/psychoactives5020012 (opens in new tab)
Psilocybin
Protocol science
Complicated grief
Randomized controlled trial
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