Environmentally Friendly Expeditious One-Pot Electrochemical Synthesis of Bis-Catechol-Thioether Metabolites of Ecstasy: in vitro Neurotoxic Effects in the Rat Hippocampus
International Journal of Electrochemical Science February 9, 2026 Anne Felim, Anne Neudörffer, François P. Monnet et al.
A straightforward one-pot electrochemical synthesis of bis-catechol-thioether metabolites of MDMA (ecstasy), 2,5-bis(glutathion-S-yl)-N-methyl-α-methyldopamine and 2,5-bis(N-acetylcystein-S-yl)-N-methyl-α-methyldopamine, in acceptable yields and high degree of purity (99%), is described under environmentally friendly conditions. The undeniable benefits of this method, which uses...