François P. Monnet

2 papers in the library · publishing 2009-2026

Papers

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Environmentally Friendly Expeditious One-Pot Electrochemical Synthesis of Bis-Catechol-Thioether Metabolites of Ecstasy: in vitro Neurotoxic Effects in the Rat Hippocampus

International Journal of Electrochemical Science February 9, 2026 Anne Felim, Anne Neudörffer, François P. Monnet et al.

A straightforward one-pot electrochemical synthesis of bis-catechol-thioether metabolites of MDMA (ecstasy), 2,5-bis(glutathion-S-yl)-N-methyl-α-methyldopamine and 2,5-bis(N-acetylcystein-S-yl)-N-methyl-α-methyldopamine, in acceptable yields and high degree of purity (99%), is described under environmentally friendly conditions. The undeniable benefits of this method, which uses...

DOI: 10.1016/s1452-3981(23)15452-6 Full text Ecstasy Anodic oxidation In vitro neurotoxicity Quinone +1

[Metabolites of ecstasy and cytotoxicity effects].

Annales pharmaceutiques francaises March 2009 M-B Fleury, Anne Neudörffer, Anne Felim et al.

Intracerebroventricular injection of methylenedioxymethamphetamine (MDMA, ecstasy) in rats fails to reproduce long-term toxic effects observed after peripheral administration. Therefore, systemic metabolites would play an essential role in the development of cytotoxicity. In humans, the major metabolite is the 3,4-dihydroxymethamphetamine derivative (HHMA), which is easily oxidizable to the...

DOI: 10.1016/j.pharma.2008.12.002 Full text