Maria D Gutierrez-Lopez

2 papers in the library · 8 citations · publishing 2011-2021

Papers

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Increased kynurenine concentration attenuates serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats through activation of aryl hydrocarbon receptor.

Neuropharmacology February 16, 2021 C. Abuin-Martínez, Rebeca Vidal, Maria D Gutierrez-Lopez et al.

3,4-Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative that has been shown to produce serotonergic damage in the brains of primates, including humans, and of rats. Tryptophan, the precursor of serotonin, is primarily degraded through the kynurenine (KYN) pathway, producing among others KYN, the main metabolite of this route. KYN has been reported as an endogenous agonist of the...

DOI: 10.1016/j.neuropharm.2021.108490

Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA

Journal of Neuroinflammation December 1, 2011 Andrea Mayado, Elisa Torres, Maria D Gutierrez-Lopez et al. 8 citations

AbstractBackgroundPreconditioning is a phenomenon by which tolerance develops to injury by previous exposure to a stressor of mild severity. Previous studies have shown that single or repeated low dose MDMA can attenuate 5-HT transporter loss produced by a subsequent neurotoxic dose of the drug. We have explored the mechanism of delayed preconditioning by low dose MDMA.MethodsMale Dark Agouti...

DOI: 10.1186/1742-2094-8-165