Rewiring Receptor Activation: Mechanistic Insights into Toggle Switch Modulation by 25CN-NBx Compounds
ACS Chemical Neuroscience February 18, 2026 Vito F. Palmisano, Micaela Vidal−sánchez, Juan J. Nogueira
High Resolution Image Download MS PowerPoint Slide The development of new treatments for neuropsychiatric disorders relies on a deeper understanding of the molecular mechanisms behind psychedelic compounds, particularly how they differentiate between hallucinogenic and antidepressant effects. In this study, we explore by molecular dynamics simulations a series of 25CN-NBx compounds bound to the...
DOI: 10.1021/acschemneuro.6c00023 (opens in new tab)
Dihedral angle
Molecular dynamics
Receptor
Molecular mechanics
+4