Ketamine Metabolites Promote Anxiolysis and Hydrocortisone Stress Buffering in Zebrafish.
Behavioural Brain Research July 9, 2026 Jeffrey R Kelly, Lindsey S Brasfield, Aryssa H Kelsey et al.
Anxiety and stress-related disorders affect over 280 million individuals worldwide and remain inadequately treated by current pharmacotherapies, which are often limited in efficacy and tolerability. Ketamine produces rapid therapeutic effects in mood and anxiety disorders, but its clinical use is constrained by dissociative side effects and abuse liability. Ketamine metabolites, particularly (2...