NMDA receptor subtype differential affinity as a key enabler for precision neuropsychiatry.
Progress in neuro-psychopharmacology & biological psychiatry June 20, 2026 Aline Freyssin, Reina Benabou, Hanna Zoe Müller et al.
Despite recent advances in neuropsychiatry, translational development for many targets remains challenging, particularly when receptors exist as families with complex subunit-dependent pharmacology and safety concerns. This is the case for NMDA receptor (NMDAR) antagonists. R,S-ketamine illustrates this issue: although it produces rapid antidepressant effects in the clinic, its use is limited...