Modulatory effects of ketamine on EEG source-based resting state connectivity in treatment resistant depression.
Translational Psychiatry March 6, 2026 Ty Lees, Jason N Scott, Brian W. Boyle et al.
Treatment-resistant depression (TRD) accounts for approximately 30% of major depressive disorder cases and has been characterized by altered functional connectivity within and between the Default Mode (DMN) and Frontoparietal networks (FPN). Ketamine can be an effective treatment for TRD, and its antidepressant response has been associated with alterations in resting state functional...