Despite the availability of many treatment options, several individuals with bipolar disorders experience persistent symptoms, necessitating the exploration of novel therapeutic approaches. In recent years, there has been a growing interest in repurposing drugs of abuse, such as stimulants, ketamine, and psychedelics, for the treatment of bipolar disorders. While some of these drugs have...
Racemic ketamine is a mixture of (R)-ketamine (arketamine) and (S)-ketamine (esketamine), with the latter regarded as the main isomer for antidepressant effects. However, preclinical data and one open-label human trial suggest arketamine might exert a more potent and longer-lasting antidepressant effect with fewer side effects. We aimed to explore the feasibility of a randomized controlled...