Adolescent ketamine exposure impairs spike timing-dependent plasticity and GABAergic transmission in pyramidal neurons of the mouse prefrontal cortex.
The Journal of Physiology June 1, 2026 Felipe Guiffa-Gómez, Sashá Van Buuren, Freddy Aguilar et al. 1 citation
The medial prefrontal cortex (mPFC) undergoes extensive GABAergic interneuron maturation during adolescence, a process that establishes excitatory-inhibitory balance and supports adult cognitive function. Disruptions during this critical developmental period contribute to neuropsychiatric disorders, yet the enduring consequences for adult synaptic plasticity remain poorly understood. Here we...