Kuan-I Liu

2 papers in the library · publishing 2026

Papers

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Symptom-level and network analyses of ketamine treatment in treatment-resistant depression: A pooled analysis of two randomized controlled trials.

Progress in neuro-psychopharmacology & biological psychiatry September 26, 2026 Kuan-I Liu, Wei-Chen Lin, Cheng-Ta Li et al.

We examined symptom-level treatment effects and exploratory symptom networks after ketamine in treatment-resistant depression. This post hoc analysis pooled 132 participants assigned to ketamine 0.5 mg/kg or protocol-specific control (66 each) from saline-controlled 2017 and midazolam-controlled 2023 trials. Baseline- and trial-adjusted models assessed Montgomery-Åsberg Depression Rating Scale...

DOI: 10.1016/j.pnpbp.2026.111950 Full text Ketamine Treatment-resistant depression Network intervention analysis Symptom network

Distinct therapeutic profiles of ketamine in treatment-resistant depression: an exploratory analysis.

The International Journal of Neuropsychopharmacology May 3, 2026 Kuan-I Liu, Wei-Chen Lin, Cheng-Ta Li et al.

Intravenous ketamine demonstrates rapid efficacy for treatment-resistant depression (TRD). However, its impact on individual depressive symptoms and whether the degree of treatment resistance moderates these effects remain unclear. This study aimed to dissect symptom-specific trajectories and examine the moderating role of the degree of treatment resistance. We conducted a post-hoc analysis of...

DOI: 10.1093/ijnp/pyag021 Full text Ketamine Treatment-resistant depression Maudsley staging method Precision medicine +1