How ketamine works: An actionable hypothesis.
Proceedings of the National Academy of Sciences of the United States of America May 5, 2026 Roberto Malinow
Ketamine has been shown to reduce depression and suicidality in individuals resistant to treatment by other drugs. Exactly how ketamine works is not known. Here, I propose a new hypothesis that involves synaptic and circuit plasticity and may lead to enhanced efficacy in treating depression as well as other conditions.