Ketamine-related neural changes in treatment-resistant depression: A multimodal synthesis of fMRI and PET studies.
Journal of Affective Disorders April 28, 2026 Nesreen Sedeek, Carley Rivers, Lucas Williamson et al.
Ketamine produces rapid antidepressant effects in a subset of patients with treatment-resistant depression, yet neuroimaging findings have been difficult to integrate because studies differ in imaging modality, analytic approach, task context, and post-infusion timing. To address this, we conducted a multimodal synthesis of functional magnetic resonance imaging (fMRI) and positron emission...