Chronic corticosterone biases conflict-related behavior and abolishes ketamine's anticonflict effect in mice.
Journal of Pharmacological Sciences August 1, 2026 Natsuko Hitora-Imamura, Yuki Nishida, Koki Kawazoe et al.
Animals must balance reward seeking against potential danger, and impairments in such conflict decision-making are common in psychiatric disorders. Here, we examined how chronic corticosterone exposure and ketamine affect conflict behavior in mice by presenting them with a three-compartment conflict task. Three weeks of corticosterone increased conflict levels without inducing anhedonia,...