Ketamine alters the aperiodic EEG exponent in major depression: implications for cortical E/I balance and treatment prediction.
Therapeutic Advances in Psychopharmacology 2026 Yujuan Liu, Xiaorong Liu, Sebastian Olbrich et al.
Ketamine has emerged as a promising rapid-acting antidepressant for treatment-resistant depression (TRD), yet its mechanisms of action and reliable biomarkers of treatment response remain poorly understood. Recent evidence suggests that the aperiodic exponent (1/f slope) of electroencephalography (EEG) power spectra reflects cortical excitation-inhibition balance (EIB), offering a potential...