Abstract The initial chemical synthesis of MDMA was in 1912 (33). The drug was originally prepared as an anorectic agent but was never marketed for this purpose. MDMA forms salts with several acids and, as such, is a white solid at room temperature. It is soluble in water and has a bitter taste (33 ). The ( + )-(S)-isomer and the (-)-(R)isomer exhibit somewhat different pharmacological and...