A Systematic Review of MDMA’s Effects on Social Functioning in Placebo-Controlled Trials
May 4, 2026 Victoria Burmester, Laura Aggett, David Nutt et al. preprint
Background3,4-Methylenedioxymethamphetamine (MDMA) is associated with distinctive prosocial and empathogenic effects, yet the consistency and scope of its impact on social functioning in humans remain unclear. Although numerous placebo-controlled studies have examined MDMA’s acute social effects, findings vary widely across subjective and behavioural domains.MethodsWe conducted a systematic...