Dual Modulation of 5-HT2A Receptors and SERT by α-Ethyltryptamine and Its Optical Isomers.
ACS Chemical Neuroscience December 17, 2025 Justin M Silverman, Michael Fiorillo, Jason Younkin et al. 1 citation
α-Ethyltryptamine (AET), a synthetic tryptamine formerly used as an antidepressant, has resurfaced as a compound of interest due to its structural and functional overlap with serotonergic psychedelics and entactogens. Here, we characterized the pharmacological properties of racemic AET and its optical isomers, R(-)-AET and S(+)-AET, focusing on their interactions with the serotonin (or...
DOI: 10.1021/acschemneuro.5c00468 (opens in new tab)
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5-ht2a receptor
G protein-coupled receptor
Head-twitch response
Psychedelics
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