Elizabeth J. Brouns

Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration.

Psychedelics April 22, 2025 Elizabeth J. Brouns, Tyler G. Ekins, Omar J. Ahmed

Psychedelic compounds have demonstrated remarkable therapeutic potential for treating neuropsychiatric disorders by promoting sustained neuroplasticity in the prefrontal cortex (PFC). Cognitive flexibility-the ability to adapt previously learned rules to novel situations-represents a critical PFC function that is frequently impaired in depression, PTSD, and neurodegenerative conditions. In this...