Amanda M. Weiner

Psilocybin reshapes cortical inhibition through selective interneuron recruitment.

bioRxiv : the preprint server for biology April 17, 2026 Pasha A. Davoudian, Quan Jiang, Cory A. Knox et al. preprint

Psychedelics show therapeutic potential for treating psychiatric disorders. While studies have emphasized the roles of cortical pyramidal cells, GABAergic neurons also express serotonin receptors and are therefore likely targets of psychedelics. In this study, we determine the effect of psilocybin on the activity dynamics of major GABAergic cell types in the mouse medial frontal cortex....